Carling Cup holders Tottenham Hotspur travel to Watford tonight, and Manchester United host Blackburn Rovers as the last two Quarter-Finals get underway.
With Burnley and Derby already safely through, the Hornets would love to make it three teams from the Championship but new boss Brendan Rodgers is looking forward to pitting his wits against the Premier League side:
"To come into the club and go straight into a quarter-final is a great opportunity.
"The club has had four semi-final appearances in the last eight years which is incredible so we are all looking forward to it.
"The league is obviously very important, it's the crux of what we do but I would certainly not say that a Carling Cup quarter-final is a hindrance."
Harry Redknapp has had a fantastic impact since taking charge at White Hart Lane at the end of October, winning seven of the 10 games played but Watford will be hoping it's them that's smiling tonight.
Paul Ince goes head to head with his former Manager Sir Alex Ferguson tonight, in his first return to Old Trafford as a Manager.
Ince has enjoyed a difficult start to life in charge of Blackburn Rovers, with them currently sitting second bottom of the Premier League table but he is looking forward to a change of attention.
Speaking to Blackburn's official website Ince said:
"We are at the business end of the competition and there is plenty to play for. To go there and succeed would give us a very timely boost although we accept that the draw could hardly have made it more difficult for us.
"We don't know what starting eleven Sir Alex (Ferguson) is going to put out, but you can be guaranteed that it will be a good one and we will have to be at our best."
Sir Alex Ferguson is expected to make wholesale changes to his side, who will definitely be without Cristiano Ronaldo, following his sending off on Sunday.
The winners of tonight's tie will go into Saturday's draw for the Carling Cup Semi-Finals which takes place during Sky Sports Soccer Saturday from 12pm.