Bristol Rovers bounced back from their weekend defeat to Darlington with an emphatic 6-3 win away at Wycombe Wanderers.
The win came largely due to the hat-trick from Pirates striker Jo Kuffour who doubled his tally for the season. While there will be a fight for the match ball after Wycombe striker Scott Rendell also scored three.
The former Arsenal trainee got the ball rolling with his first of the night on 22 minutes and then doubled the advantage five minutes before the break.
Scott Rendell pulled a goal back for the home side on 58 minutes but just a minute later Kuffour completed his hat-trick and restored the two goal advantage.
It appeared all over for the Chairboys on 62 minutes when Chris Lines made it 4-1 with his fourth goal of the season.
Jo Kuffour then rounded off an excellent night for Paul Trollope's side when he won a penalty, after being bought down by Alan Bennett. Jeff Hughes stepped up to take the spot kick and made no mistake, scoring his sixth of the season.
There was still time for Scott Rendell to score a second of the night, when he also converted from the penalty spot, after he was bought down. He dusted himself off and made no mistake to score his first double in 18 months.
The former Peterborough striker then completed his hat-trick with just a minute to go but in the end it wasn't enough to stop his side going out of the competition.
Ben Swallow completed the scoring when he scored his first senior goal deep in injury time to earn his side a 6-3 win.
Huddersfield Town were also in the goals as they won the Yorkshire derby beating Rotherham United 5-2 on their own turf.
Lee Clark's side were ahead with just a minute on the clock when Jordan Rhodes scored his first of the night but the League 2 side hit back through Ryan Taylor who equalised 10 minutes later.
Rhodes grabbed his second on 23 minutes before Benik Afobe scored his first senior goal, after signing on loan from Arsenal. The 17-year-old was making only his second start for the club and needed just 28 minutes to open his account to fire the Terriers 3-1 ahead.
Scott Arfield added to the scoring on 52 minutes before Afobe netted his second of the night and Town's fifth to earn their place in Saturday's area semi-final draw.
Ryan Cresswell pulled a goal back for the home side deep in injury time but it was nothing more than a consolation, as Rotherham's winless streak at home to six games.
Brentford won their third penalty shoot-out of the season, as they came from a goal down to draw 1-1 with Swindon Town.
Charlie Austin fired his side in front with just 12 minutes on the clock, at the County Ground, but Robbie Simpson equalised before the break.
Neither side could break the deadlock in the second half so penalties loomed and the Bees, who suffered shoot-out heartache against Birmingham City in the last round of the Carling Cup, triumphed, winning 4-2.
Three more sides up against lower league opposition came through safely as Tranmere Rovers beat Bury, Carlisle United saw off the challenge of Crewe Alexandra and Charlton Athletic won at Southend United.
Rovers took the lead after just eight minutes at Gigg Lane, as Ian Thomas-Moore scored his fourth goal in as many games. In the end it proved to be enough to see Les Parry's side through.
Clayton Donaldson scored in both ends as Crewe went down 3-1 to Carlisle at Brunton Park.
The former York City striker put through his own goal to give the home side the lead on 14 minutes. Peter Murphy then doubled the lead on 72 minutes but just four minutes later Donaldson was on target again this time in the right net, to give the visitors hope but that was soon over when Murphy scored his second of the night.
At Roots Hall a first half goal from Therry Racon was enough to see Phil Parkinson's side through as they secured a 1-0 win over Southend.