Youssouf M'Changama is expected to miss the rest of the season as Oldham continue to count the cost of their FA Cup heroics against Liverpool.
Shortly after providing the cross for Matt Smith to open the scoring in Sunday's famous 3-2 triumph, M'Changama sustained a knee injury from a challenge that earned Reds winger Raheem Sterling a booking.
Although scans showed no cartilage or cruciate ligament damage for the 22-year-old left-sided midfielder, he has suffered a snapped medial ligament.
"There's a good chance it could be the season, unfortunately," Latics boss Paul Dickov confirmed.
"He's snapped his medial ligament, which is unfortunate because the kid was coming into a bit of form as well."
Two-goal hero Smith picked up a shoulder injury during the closing stages, while strike partner Robbie Simpson also failed to complete the 90 minutes due to a hamstring tear.
Dickov added: "We're light on numbers anyway and it looks as if Robbie and Matt are going a few weeks as well.
"Robbie's got a slight tear on his hamstring, Matt's torn some cartilage in his shoulder."