Brentford v Colchester United
Brentford have struggled to hit form so far this term and entertain Colchester United.
The Bees made the Play-Off Final last season but have begun this time around with four wins, three draws and four defeats in their first 11 games, to sit 11th. They have lost three of their last four.
Colchester haven't tasted a victory since August 10th, nine matches ago. They've also lost the most recent two clashes with Brentford.
Crawley Town v Bradford City
Crawley Town are unbeaten in six and face Bradford City - a team they've never lost to.
The Red Devils are on a run of three draws and three wins, sitting ninth, while City are fourth but lost to lowly Tranmere in their last match, on Sunday.
The two teams have only clashed twice, with Crawley taking all three points on both occasions. They won 3-1 at home in September 2011 before running out 2-1 victors at Valley Parade in March 2012.
Crewe Alexandra v Bristol City
Bristol City are still awaiting their first victory and travel to Crewe Alexandra.
The Robins are 23rd in the division with six points - all from draws. Three of their most recent four have ended level, including their last outing, against Port Vale, but they led up until a poor Aden Flint back-pass in stoppage time allowed Vale to snatch a point.
Crewe ended their own wait for a victory, which stretched seven matches, last time out by overcoming Preston 2-0.
Gillingham v Preston North End
Peter Taylor begins his second spell in charge of Gillingham with a match at home to Preston North End.
The 60-year-old was named interim manager at the Priestfield Stadium following last Sunday's sacking of Martin Allen, with the Gills sitting 17th on nine points.
Preston are fifth but they have succumbed to two defeats on the spin, against Peterborough and Crewe Alexandra.
Martin Allen was sacked by Gillingham last weekend, and replaced by interim manager Peter Taylor
Milton Keynes Dons v Rotherham United
It's sixth against eighth at stadiummk with Rotherham United visiting Milton Keynes Dons.
The Millers are the higher of the two with 19 points, just inside the Play-Off places, but they have never overcome the Dons in a League match.
Three of the four League meetings between the two clubs have ended level, with eighth-placed Milton Keynes, who have lost their two most recent outings this term, winning the other 1-0 in January 2008.
Oldham Athletic v Carlisle United
Carlisle United take their four-match unbeaten run to Oldham Athletic.
The Cumbrians have surged up the table with three victories and a draw under the stewardship of newly-appointed boss Graham Kavanagh, who replaced Greg Abbott.
Oldham haven't won since late August with four defeats and two draws in their last six matches.
Peterborough United v Shrewsbury Town
Darren Ferguson's high-flying Peterborough United host mid-table Shrewsbury Town.
Posh are second and come into the match on the back of five successive wins, most recently against Port Vale, while the Shrews beat Gillingham 2-0 last Saturday.
The two sides haven't clashed since the 2007/08 League 2 campaign and Peterborough completed the double that term, winning 2-0 and 2-1.
Sheffield United v Port Vale
Micky Adams takes his Port Vale side to his former club Sheffield United, who prop up the division.
Adams managed the Blades between December 2010 and May 2011 before starting his second stint as the boss at Vale Park, and he also represented United's youth team as a player prior to his release in 1977.
Adams' Vale are 12th in League 1 with one loss in four, which came last time out, while rock bottom Sheffield United haven't claimed a victory since the opening day. They lost 3-2 to Coventry last Sunday.
Coventry City players celebrate their first goal against Sheffield United last Sunday
Swindon Town v Notts County
All the action in Sky Bet League 1 starts on Friday with Swindon Town hosting Notts County in a 7:45pm kick-off.
The Robins have been inconsistent all too often this term but they have chalked up successive victories, against Tranmere and Rotherham, prior to Friday's encounter.
County endured a torrid start to the campaign but their two wins to date have come in their last three outings, most recently 4-0 against Crewe - the same scoreline Swindon recorded against the Millers.
Tranmere Rovers v Leyton Orient
Leaders Leyton Orient are on the road on Saturday to face Ronnie Moore's Tranmere Rovers.
The O's are one of two teams that remain undefeated in The Football League this season and they beat Milton Keynes Dons last week, after notching up successive draws, to move them onto 29 points.
Tranmere are at the other end of the table with just eight points but they won 1-0 against Bradford City in their last match.
Walsall v Stevenage
Dean Smith's Walsall welcome Graham Westley's Stevenage to the Banks's Stadium.
The Saddlers are 10th on 16 points but are winless in four, drawing three of those, while the visitors bagged just their second three-point haul of the campaign last weekend, beating Brentford 2-1.
The two clubs have clashed four times. Both have one win - Walsall taking the most recent encounter - while the other two ended level.
Wolverhampton Wanderers v Coventry City
Two Midlands clubs lock horns at Molineux with Wolverhampton Wanderers entertaining Coventry City.
The last time the two sides came together was during the 2008/09 Championship season with the most recent clash ending 2-1 to the Sky Blues - their 28th win in the meeting, compared to Wolves' 21.
Coventry have fought their way out of trouble in Sky Bet League 1 to sit 16th after four wins in six, while Wolves are flying high in third after clocking up eight wins, three of which came in their most recent three matches.
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