Bradford City v Wolverhampton Wanderers
Fifth-place Bradford City host Wolverhampton Wanderers, who are third, looking to end a three-game winless spell.
The Bantams ended a run of two straight defeats with a point at Preston North End last week but face a Wolves side that have lost only once on the road this term.
The visitors to Valley Parade are unbeaten in six, having taken 14 points from a possible 18 since the 1-0 defeat to Walsall.
Brentford v Shrewsbury Town
A win for Brentford against Shrewsbury Town would make it three wins on the spin for Uwe Rosler's men and put them in contention to move into the Play-Off spots.
Shrewsbury will be aiming to pick up only a second victory in 10 outings, with six of those games ending in stalemates.
The Shrews are yet to win on the road and currently sit four points above the relegation zone in 15th.
Carlisle United v Bristol City
Bristol City remain in search of their first win of the season, at Carlisle United.
The league's bottom markers have failed to win any of their opening 12 games and are now the only team in League 1 yet to pick up a victory.
The mid-table Cumbrians are in-form, having won four of their last six, and will fancy their chances of continuing their climb up the table by registering a third victory of the season against City.
Colchester United v Peterborough United
Two extremes of the form-book meet at the Weston Homes Community Stadium with high-flying Peterborough United taking on Colchester United.
Posh have six victories in eight and meet a U's side who are without a win in 11 league games, and have won just once at home.
In contrast, Darren Ferguson's side have picked up five wins from six games away from London Road, notching 16 goals in the process.
Leyton Orient v Rotherham United
Leaders Leyton Orient lost their unbeaten record in midweek with a 3-1 defeat at Coventry City, but boast the league's best home record, ahead of their meeting with Rotherham United.
Russell Slade's free-scoring O's will be aiming to get back on their feet against a Rotherham side looking to end a run of three games without victory.
Steve Evans' Millers were denied a win by Ryan Lowe's late penalty for Tranmere on Tuesday night - that 1-1 draw put a stop to two straight defeats.
Notts County v Preston North End
Both of Notts County's league wins this season have come at Meadow Lane, which will give them confidence as they entertain a Preston North End side sitting pretty in fourth.
The Magpies last three home games have ended in victory, beginning with the 1-0 win over Burton Albion in the Johnston's Paint Trophy, but they must stop a Preston side who have won three of their last four on the road.
County's recent run against North End has been poor, with Chris Kiwomya 's side without a win against the Lilywhites since 2000.
Oldham Athletic v Swindon Town
Just two points separate 19th-place Oldham Athletic and Sheffield United, who are in the last relegation spot, ahead of the Latics' home match with Swindon Town.
The travelling Robins are the same margin away from the Play-Off zone following defeat to Walsall in midweek; a result that ended their run of four wins from four.
Mark Cooper's side have triumphed just once away from the County Ground, while Oldham have registered a mixed bag of results at Boundary Park, notching two wins, two draws and two defeats from their six games.
Port Vale v Gillingham
Five points separate Port Vale in 12th and Gillingham in 17th as the pair meet at Vale Park.
Micky Adams will be looking to build on the home side's 3-0 win at Crawley Town in the week, which ended a run of four matches without a three-pointer.
At the same time, the Gills were busy picking up a first win under interim boss Peter Taylor after two straight defeats, though the visitors will have to improve on their form away from the Priestfield Stadium, having registered only four points on their travels.
Sheffield United v Crewe Alexandra
Four points from their last two run-outs has moved Sheffield United to within three points of moving out of the relegation zone. They entertain Crewe Alexandra.
Victory for the Blades on Saturday, in what will be Nigel Clough's first game in charge, would draw them level on points with their opponents.
Alex possess the unenviable title of the league's leakiest defence and Steve Davis' Railwaymen suffered a surprise 3-0 defeat to Stevenage in the week, but had won the two games prior to that.
Nigel Clough will return to the touchline this weekend for his first game as manager of Sheffield United
Stevenage v Crawley Town
After their 3-0 win against Crewe, Stevenage host Crawley Town.
The Red Devils are three points away from sixth-placed Walsall following a midweek reverse against Port Vale.
Graham Westley's men have picked up three wins from four but only have one home win so far this season.
Tranmere Rovers v Milton Keynes Dons
Tranmere hold the division's worst home record going in to their clash with MK Dons at Prenton Park.
A return of just two points from six games at home and one win in eight has left Rovers 22nd.
Karl Robinson's Dons have only managed one three-point haul on the road, however a win could see them enter the top six.
Walsall v Coventry City
Walsall could be in fourth place by the end of play if they can dispose of Coventry City at the Banks's Stadium.
The Sky Blues are in form however, having won three of their last four and will be full of confidence after defeating Leyton Orient 3-1 on Tuesday night, and thus ending League 1s only unbeaten record.
The Saddlers have won their last two and have only suffered one loss in eight.
Carl Baker got the ball rolling for Coventry in midweek by scoring the first goal in their 3-1 triumph against leaders Leyton Orient
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