Bradford City v Leyton Orient
Bradford City, eighth in the Sky Bet League 1 table, host leaders Leyton Orient at Valley Parade on Saturday.
Although the Bantams are unbeaten in five league matches, Phil Parkinson's men have only registered one win in nine. That run of eight points from 27 available has seen the Yorkshiremen slip outside the Play-Offs.
Orient have been trading top spot with Wolves in recent weeks, and returned to the summit after a draw against Sheffield United last time out. Russell Slade's men have the best away return in the division, with seven wins, two draws and one defeat on the road.
Brentford v Oldham Athletic
Mark Warburton takes charge of Brentford for the first time as they host Oldham Athletic.
Uwe Rosler left the Bees last weekend before they crashed out of the FA Cup at Carlisle United, but the Griffin Park side are unbeaten in eight league games, winning seven.
14th-placed Oldham are unbeaten in four Sky Bet League 1 matches, but the Latics haven't netted in 380 minutes of football against Brentford, losing their last four clashes without scoring.
Bristol City v Rotherham United
Bristol City have the second worst home record heading into their weekend fixture against Rotherham United at Ashton Gate.
The West Country side are the only team in the division not to have won at least twice at home, only picking up eight points from 30. Their solitary triumph at Ashton Gate was a 2-0 win over Crawley last month.
Going into the 51st meeting between these two, Rotherham are the form side having won three and drawn two of their last five. However, they were dumped out of the Johnstone's Paint Trophy by League 2 side Fleetwood on Tuesday.
Carlisle United v Tranmere Rovers
Carlisle United and Tranmere Rovers are separated by one point heading into their weekend encounter at Brunton Park.
In six Sky Bet League 1 games, Graham Kavanagh's Cumbrians have picked up just one win - a 2-1 home triumph over struggling Crewe. That has seen them drop to 18th, although they did beat Brentford 3-2 in the FA Cup last weekend.
Tranmere have risen out of the relegation zone into 19th position thanks to a run of seven games with just one defeat, although they were humiliated 5-0 by Peterborough in the FA Cup last time out.
Colchester United v Notts County
The division's worst away record belongs to Notts County, who make the trip to Colchester United.
Shaun Derry picked up his first win as boss of the Magpies when they were 3-1 victors over Gillingham in the league last Saturday, but they have just two points from 30 away from Meadow Lane. County and Sheffield Wednesday are the only Football League teams without a victory on the road this season.
Joe Dunne's team will be refreshed after a two-week break owing to their elimination from the FA Cup in the first round. They lost 2-1 at Tranmere last time out.
Coventry City v Crewe Alexandra
Coventry City and Crewe Alexandra meet this weekend in their 23rd encounter, with goals expected.
The Sky Blues' home games have seen 45 strikes in 10 matches, the highest number in the division, but they've lost their last two on their own patch, 3-0 to Rotherham and 5-1 to Tranmere. Steven Pressley saw his side win 3-1 at Milton Keynes Dons last time out in League 1.
Whereas Coventry sit comfortable mid-table, the Railwaymen are struggling in second-bottom. They have conceded the most goals in League 1, 40, and have the worst goal difference at minus 25. After no win in six, they beat Crawley 1-0 two weeks ago.
Tranmere's Ryan Lowe celebrates scoring in the Rovers' resounding win against Coventry at Sixfields
Crawley Town v Preston North End
John Gregory takes charge of his first home game as Crawley manager with the visit of Preston North End.
The Red Devils picked up a 0-0 draw at Bristol Rovers in the FA Cup under Gregory, continuing their drought in front of goal. The Surrey side haven't won in eight league matches, scoring just once.
Preston are third and closing in on table-toppers Leyton Orient, whom they trail by six points after a run of five wins in eight unbeaten games. North End's only away defeat came at Peterborough United.
Gillingham v Peterborough United
Peterborough are two points and two places behind Preston, and make the trip to Kent to face Gillingham this weekend.
Posh have won three in a row after victories in the league, FA Cup and Johnstone's Paint Trophy, arresting a six-game losing streak in League 1.
The Gills have lost their last two, conceding seven goals, but have had two weeks off after being knocked out of the FA Cup in the first round. This will be the first meeting between these two for 16 years.
Peterborough's Michael Bostwick fires home the only goal of the game against Wolves last time out in the league
Port Vale v Stevenage
Ninth-placed Port Vale take on Stevenage, in 21st, at Vale Park on Saturday.
Micky Adams' side are just two points off Rotherham in the final Play-Off place after a run of five wins in seven, and comfortably dispatched non-league Salisbury in the FA Cup.
Stevenage are in stuttering form with a lonely victory in five league matches, but that was an impressive 1-0 win at Peterborough. Their only two visits to Vale have garnered a draw and a win.
Sheffield United v Swindon Town
Swindon Town, who knocked Stevenage out of the Johnstone's Paint Trophy on penalties on Tuesday, make the journey north to face Sheffield United.
Victories against the Yorkshiremen are hard to come by for the Robins, with the Blades currently unbeaten in their past eight meetings. The Wiltshire club have come away from Bramall Lane without success on the last 12 occasions, since a 2-1 win in February 1970.
Swindon are the higher ranked team heading into this clash, however. They sit seventh with 30 points - 13 richer than Nigel Clough's 20th-placed side.
Shrewsbury Town v Walsall
Shrewsbury Town and Walsall face each other with almost identical records at home and away respectively.
At the Greenhous Meadow in the league, the Shrews have won four, drawn four, and lost two, with a goal difference of plus five. The Saddlers have the same 16-point return on the road, but have scored one goal fewer in their respective matches.
These teams have already met once this season, in the first round of the FA Cup last month, when Dean Smith's side were 3-0 victors over the Shropshire club.
Wolverhampton Wanders v Milton Keynes Dons
Wolverhampton Wanderers and Milton Keynes Dons meet for the first time ever, at Molineux on Saturday.
Second-placed Wolves hold the best home record in the division, with 23 points out of 30. Kenny Jackett has seen his side concede only five times in 10 games in the Black Country, with their one defeat against Walsall.
Despite being 12th in the league, MK Dons have the fourth worst away record. After drawing two and winning one in their first three matches on the road, the Dons have lost their next five, picking up five points from eight games.
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