Accrington Stanley v Rochdale
Bottom of the table Accrington Stanley will be aiming for their first win of the campaign when they host Rochdale.
James Beattie's men have registered just one point this term and are amidst a five-game winless run, while the Dale have had an indifferent start with three victories, two draws and two losses.
There has only been one clean sheet kept between the sides since 1960 but that came in their most recent meeting when Stanley won 3-0 back in February.
AFC Wimbledon v Burton Albion
Two teams with two losses to their name meet at the Cherry Red Records Stadium as AFC Wimbledon welcome Burton Albion.
After finishing last season two points above the drop zone, the Wombles have opened the campaign with 13 points from their seven games, but lost 2-0 against Chesterfield last time out.
The Brewers are two points further adrift and have been defeated in their last two matches - 2-0 against Oxford United and 2-1 to Portsmouth.
Bristol Rovers v Hartlepool United
Hartlepool United registered their first win of the term last weekend and they travel to Bristol Rovers on Saturday.
Pools beat Accrington Stanley 2-1 with first-half goals from Jonathan Franks and Andy Monkhouse to secure their opening three-point haul, while John Ward's Pirates fell to their second successive loss, at Dagenham and Redbridge.
It has been even between the two teams in recent league meetings with each notching six wins, with six finishing level.
Jonathan Franks' first league goal of the season set Hartlepool United on their way to a 2-1 win over Accrington Stanley last weekend
Bury v Southend United
Southend United have lost their last four matches and they are at Bury.
After starting the season with three successive wins, the Shrimpers have gone on to lose against Chesterfield, Wycombe Wanderers, Morecambe and, most recently, Scunthorpe United.
Kevin Blackwell's men are two places and two points behind Southend and are also riding a losing streak. Since beating Cheltenham Town 4-1 in their last home game, the Shakers have been defeated by Rochdale and Fleetwood Town.
Exeter City v Newport County
Fourth-placed Exeter City entertain a Newport County side without a win in four games.
The Grecians fought back from a losing position in their last match against Northampton Town to secure all three points, with John O'Flynn grabbing a last-gasp winner.
County made it difficult for themselves in their encounter last weekend against Morecambe. Defender Tom Naylor put the ball into his own twice before conceding a second-half penalty in their 3-2 defeat.
Mansfield Town v Northampton Town
Struggling Northampton Town take their search for a second league victory to Field Mill where they face Mansfield Town.
The Cobblers have gained just one point from their last five outings and lost from a winning position against Exeter last weekend.
Mansfield have had a strong return to The Football League after promotion last season. The Stags are undefeated since the opening day and they beat York City 2-1 last time out with Ollie Palmer netting the winner.
Morecambe v Dagenham and Redbridge
After winning four league matches on the spin, Morecambe host Dagenham and Redbridge at the Globe Arena.
The Shrimps stuttered in their opening three games with two losses and a draw before embarking on their current strong run. Wayne Burnett's Daggers have had an indifferent start to the campaign with two victories, two losses and three draws.
The last five encounters between the two sides have ended with a 2-1 scoreline and Morecambe have triumphed in four of them.
Oxford United v Chesterfield
This weekend's stand-out game in Sky Bet League 2 sees the top two clash at the Kassam Stadium where Oxford United entertain Chesterfield.
A four-point gap between the two undefeated sides was built last week as Chris Wilder's men could only muster a 2-2 draw against Cheltenham Town - their third draw of the term - while the Spireites ran out 2-0 winners against AFC Wimbledon to maintain their strong start.
Chesterfield got the better of the U's last season, both home and away, with a 2-1 win at the Proact Stadium in November before a 1-0 away success in March.
Dave Kitson scored his first Oxford United goal in the U's 2-2 draw against Cheltenham Town last Saturday
Portsmouth v Fleetwood Town
Portsmouth and Fleetwood Town meet for the first time this weekend at Fratton Park.
The Cod Army come into the fixture in third with five wins and two losses on the board, while Guy Whittingham's men are 13th with nine points from their seven league matches.
Both teams registered 2-1 wins last weekend - goals from Ricky Holmes and Simon Ferry lifted Pompey past Burton, and Fleetwood came from behind to beat Bury with strikes from Antoni Sarcevic and Gareth Evans.
Scunthorpe United v Plymouth Argyle
After winning their first game since the opening day, Scunthorpe United welcome Plymouth Argyle on Saturday.
The Iron overcame Southend 1-0 to record that long-awaited victory and that saw them rise to 11th in the table on 10 points. John Sheridan's Pilgrims lost 3-0 against Wycombe Wanderers.
Meetings between the teams have gone in the favour of home club in recent years - the last victory for a travelling side coming back in 1998.
Torquay United v Cheltenham Town
Cheltenham Town make the trip to Devon this weekend to take on Torquay United.
Both sides are locked on six points but Mark Yates' men have a better recent record having drawn their last two games, against Portsmouth and Cheltenham.
Alan Knill's side have fallen to defeats against Fleetwood and Rochdale in their last two games.
Wycombe Wanderers v York City
York City go in search of their first league win since the opening day of the season, at in-form Wycombe Wanderers.
The Minstermen have picked up just one point since overcoming Northampton six games ago and they were beaten 2-1 by Mansfield in their most recent outing.
Gareth Ainsworth's Chairboys have started the campaign strongly and have won their last three matches, beating Southend and Hartlepool 2-1 before last Saturday's 3-0 triumph at Plymouth.
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