Accrington Stanley v Oxford United
Bottom-markers Accrington Stanley are still yet to secure a league victory this season, and changing that won't come easy with the visit of third-placed Oxford United to the Crown Ground.
August's Capital One Cup win at Middlesbrough will have had Stanley fans dreaming of a stress-free season, but that remains their only win of the season to date.
The U's have been solidly picking up points, quickly putting a stop to two defeats on the bounce last weekend with victory over Northampton Town, and with 21 goals scored, they boast the division's most potent attack.
Bristol Rovers v Wycombe Wanderers
Bristol Rovers welcome the visit of Wycombe Wanderers.
Seven points separate Rovers in 20th and ninth-place Wycombe, though the home side have been beaten just once at the Memorial Stadium this term - a 3-1 defeat at the hands of leaders Fleetwood Town.
The Chairboys have won two, lost two, drawn one away from Adams Park, and will be motivated by the knowledge that a win could see them rise to fifth.
Cheltenham Town v Rochdale
Five wins out of their last six makes Rochdale the form team of Sky Bet League 2, sitting just three points off the top in fifth place, and they travel to Cheltenham Town.
Dale's only blot on the copy book of late is a 3-0 defeat to Portsmouth at Fratton Park at the start of the month, and the Robins have the unenviable task of stopping Keith Hill's men.
The Whaddon Road outfit have won two of their last three after having won just once in 11 games in all competitions prior to that, and are searching for just their second home win of the season.
Rochdale's Bastien Hery celebrates after netting his side's third against Newport last weekend
Chesterfield Town v Burton Albion
League-leaders Chesterfield will be looking for a kick-start against Burton Albion after stuttering lately following their five-game winning streak.
The Spireites haven't won for three league games but took a point from second-placed Fleetwood last weekend to restore confidence after two league defeats.
The mid-table Brewers beat Wycombe the last time they travelled away from the Pirelli Stadium, but that is their sole victory from their last five in the league, losing at home to Southend most recently.
Hartlepool United v Plymouth Argyle
Two wins from two has lifted Hartlepool up to 16th, three places ahead of visitors Plymouth Argyle, who will embark on a 650-mile round trip to Victoria Park.
The Pools can start to look up after victories at Mansfield Town and Exeter City, netting seven times in the process.
Goals have been hard to come by for Argyle however, with just eight netted by John Sheridan's side in 11 games. They are also without a win in five outings, with their last three points picked up on September 7th at home to Bristol Rovers.
Morecambe v AFC Wimbledon
Morecambe boast the division's longest unbeaten run, having not lost for eight games, and they host AFC Wimbledon.
The Shrimps are unbeaten at the Globe Arena so far this term, winning three and drawing two of their five home games ahead of the visit of the Wombles.
Neal Ardley's Wimbledon sit 11th and have picked up just one win on the road so far - a 2-0 victory at York.
Newport County v York City
Newport County entertain Nigel Worthington's York City.
The Exiles lost to Rochdale last week but they will be boosted by the fact that only Morecambe have left Rodney Parade with all three points this term.
York will also be playing with confidence, riding high on the back of two consecutive wins as part of a three-game unbeaten run that has seen them climb to 18th.
Northampton Town v Dagenham and Redbridge
Aidy Boothroyd's struggling Northampton Town welcome Dagenham and Redbridge following a defeat last time out to Oxford United.
Goals have been the problem for Aidy Boothroyd's men - the division's joint-second lowest scorers with Plymouth - but only four clubs have conceded more than the Daggers, who have shipped 10 in five away games.
The visitors have won just once on the road but know that a victory could put them in a Play-Off position with a quarter of the season gone.
Portsmouth v Bury
Managerless Bury visit Portsmouth's Fratton Park.
Kevin Blackwell departed Gigg Lane with the Shakers sitting 21st, without a win in six, and yet to taste success on the road.
Guy Whittingham's Portsmouth will be looking to capitalise on any uncertainty in the Bury ranks to make it three games unbeaten. They have lost three times in five matches at home, however.
Scunthorpe United v Exeter City
Three wins out of four sees Scunthorpe United on the edge of the Play-Offs and they take on Exeter City.
Brian Laws' men have been beaten just once so far, but face a Grecians side riding high in sixth.
Paul Tisdale's side head to Glanford Park on the back of a surprise 3-0 defeat at home to Hartlepool, but they have lost just once on their travels so far.
Southend United v Fleetwood Town
Southend United and Fleetwood Town kick-off the Sky Bet League 2 programme on Friday night at Roots Hall, with the hosts unbeaten in four games following four defeats on the trot.
Phil Brown's men will have to improve their home form if they are to halt Fleetwood's rise up the league though, having won just twice at on their own ground so far this term, with three of their five victories having come on the road.
The Cod Army have enjoyed their away days too, picking up 15 points on their travels. That form has helped them up to second, and another away day success would lift them above current leaders Chesterfield.
Freddy Eastwood celebrates with team-mate Barry Corr after scoring the winner against Burton last time out
Torquay United v Mansfield Town
Alan Knill's Torquay United hover just a point above the relegation zone as they host seventh-placed Mansfield Town.
The Gulls have lost three on the spin and four of their last five, and are in desperate need of a turn of fortune against a side who are also out of form, having lost two on the bounce prior to last week's draw at home to Bristol Rovers.
Five of the Stags' next seven outings will see them play away from Field Mill, but with three wins from five away from home so far, they will have plenty of confidence that they can revive their good start to the campaign.
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